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  2. Monoclonal B-cell lymphocytosis - Wikipedia

    en.wikipedia.org/wiki/Monoclonal_B-cell_lymphocy...

    Mantle cell lymphoma: The monoclonal B-cells in this aggressive lymphoma are CD5+ in most cases, CD10−, CD23−, CD43+, CD103−, complete Ig+, and express cyclin D1; these cells have translocations between chromosomes 11 and 14 in >95% of cases and in many cases overexpress the SOX11 transcription factor gene. [2]

  3. CD5 (protein) - Wikipedia

    en.wikipedia.org/wiki/CD5_(protein)

    CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3. About 76% of T-cell neoplasms are reported to express CD5, and it is also found in chronic lymphocytic leukemia and mantle cell lymphoma (both being B cell malignancies), that do not express CD3.

  4. B-cell lymphoma - Wikipedia

    en.wikipedia.org/wiki/B-cell_lymphoma

    The B-cell lymphomas are types of lymphoma affecting B cells. Lymphomas are "blood cancers" in the lymph nodes . They develop more frequently in older adults and in immunocompromised individuals.

  5. Immunoglobulin light chain - Wikipedia

    en.wikipedia.org/wiki/Immunoglobulin_light_chain

    If the lymph node or similar tissue is reactive, or otherwise benign, it should possess a mixture of kappa positive and lambda positive cells. If, however, one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell ...

  6. B-cell leukemia - Wikipedia

    en.wikipedia.org/wiki/B-cell_leukemia

    A B-cell leukemia is any of several types of lymphoid leukemia which affect B cells. [1] Types include (with ICD-O code): [citation needed] 9823/3 - B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma; 9826/3 - Acute lymphoblastic leukemia, mature B-cell type; 9833/3 - B-cell prolymphocytic leukemia; 9835/3-9836/3 - Precursor B ...

  7. Germinal center B-cell like diffuse large B-cell lymphoma

    en.wikipedia.org/wiki/Germinal_center_B-cell...

    B-cells form in the bone marrow and undergo gene rearrangement in order to develop B-cell receptors (BCRs) that bind to a specific antigen. Once activated by an antigen, B-cells proliferate and further differentiate into plasma cells and memory B-cells. [4] B-cells that have not encountered an antigen are called naive B cells.

  8. Non-Hodgkin lymphoma - Wikipedia

    en.wikipedia.org/wiki/Non-Hodgkin_lymphoma

    The most common chemotherapy used for B-cell non-Hodgkin lymphoma is R-CHOP, which is a regimen of four drugs (cyclophosphamide, doxorubicin, vincristine, and prednisone) plus rituximab. [ 33 ] R-CHP with polatuzumab vedotin , an antibody-drug conjugate, was included as a category 1 preferred regimen for first-line DLBCL by the National ...

  9. Lymphoid leukemia - Wikipedia

    en.wikipedia.org/wiki/Lymphoid_leukemia

    Lymphoid leukemias are a group of leukemias affecting circulating lymphocytes, a type of white blood cell.The lymphocytic leukemias are closely related to lymphomas of the lymphocytes, to the point that some of them are unitary disease entities that can be called by either name (for example, adult T-cell leukemia/lymphoma).

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