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The fungal protein ERG2, a C-8 sterol isomerase, falls into the same protein family as sigma-1. Both localize to the ER membrane, although sigma-1 is also reported to be a cell surface receptor. Sigma-2 is an EXPERA domain protein [4] with a mostly intracellular (ER membrane) localization. [5]
The σ 1 receptor is defined by its unique pharmacological profile. In 1976 Martin reported that the effects of N-allylnormetazocine (SKF-10,047) could not be due to activity at the μ and κ receptors (named from the first letter of their selective ligands morphine and ketazocine, respectively) and a new type of opioid receptor was proposed; σ (from the first letter of SKF-10,047). [13]
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In biology, the sigma receptor (σ–receptors) is a type of cell surface receptor. In biochemistry , the σ factor (or specificity factor) is a protein found in RNA polymerase . In bone physiology , the bone remodeling period —i.e., the life span of a basic multicellular unit—has historically been referred to as the sigma period .
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BD-1047 is a sigma receptor antagonist, selective for the σ 1 subtype. It has effects in animal studies suggestive of antipsychotic activity and may also be useful in the treatment of neuropathic pain.
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