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For example, in the early stages of transition from pro-B cell to pre-B cell, a partial rearrangement of the heavy-chain gene occurs which is followed by complete rearrangement of heavy-chain gene. [3] At this stage (Pre-B cell), the μ heavy chain and surrogate light chain are formed. [4]
JAK-STAT signalling plays an important role in animal development. The pathway can promote blood cell division, as well as differentiation (the process of a cell becoming more specialised). [24] In some flies with faulty JAK genes, too much blood cell division can occur, potentially resulting in leukaemia. [25]
A nude mouse. A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells. The phenotype (main outward appearance) of the mouse is a lack of body hair, which gives it the "nude" nickname.
Regulation of gene expression, or gene regulation, [1] includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental ...
Many of the genes listed in Table 1 play an important role in embryonic development, specifically during skeletal patterning and limb bud formation. [18] The Shh gene, and genes belonging to the BMP, Hox, T-box, FGF, and Wnt families, all play a pivotal role in cell signaling and differentiation to regulate and promote successful limb formation ...
For example, the gene encoding insulin-like growth factor 2 (IGF2/Igf2) is only expressed from the allele inherited from the male. Although imprinting accounts for a small proportion of mammalian genes, they play an important role in embryogenesis particularly in the formation of visceral structures and the nervous system. [14]
To target genes in mice, the DNA is inserted into mouse embryonic stem cells in culture. Cells with the insertion can contribute to a mouse's tissue via embryo injection. Finally, chimeric mice where the modified cells make up the reproductive organs are bred. After this step the entire body of the mouse is based on the selected embryonic stem ...
Additionally, 10-25% of human X chromosome genes, [12] and 3-7% of mouse X chromosome genes [13] outside of the PARs show weak expression from the inactive X chromosome. Random X-inactivation demands that the cell can determine if it contains more than one active X-chromosome before acting to silence any extraneous X-chromosome(s).