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Thiamine, also known as thiamin and vitamin B 1, is a vitamin, an essential micronutrient for humans and animals. [3] [4] It is found in food and commercially synthesized to be a dietary supplement or medication. [1] [5] Phosphorylated forms of thiamine are required for some metabolic reactions, including the breakdown of glucose and amino ...
Thiamine: Thiamine plays a central role in the release of energy from carbohydrates. It is involved in RNA and DNA production, as well as nerve function. Its active form is a coenzyme called thiamine pyrophosphate (TPP), which takes part in the conversion of pyruvate to acetyl coenzyme A in metabolism. [11] Vitamin B 2: Riboflavin
Benfotiamine (rINN, or S-benzoylthiamine O-monophosphate) is a synthetic, fat-soluble, S-acyl derivative of thiamine (vitamin B1) that is approved in some countries as a medication or dietary supplement to treat diabetic sensorimotor polyneuropathy. Benfotiamine was developed in late 1950s in Japan. [1] [2]
The results included sulbutiamine, fursultiamine (thiamine tetrahydrofurfuryl disulfide) and benfotiamine. These compounds are hydrophobic, easily pass from the intestines to the bloodstream, and are reduced to thiamine by cysteine or glutathione. [7]: 302 [8] It was first marketed in France by Servier in 1973 under the brand name Arcalion.
Vitamin B 1 (Thiamine) Rice bran: 1920: Vitamin C (Ascorbic acid) Citrus, most fresh foods 1920: Vitamin D (Calciferol) Cod liver oil 1920: Vitamin B 2 (Riboflavin) Meat, dairy products, eggs: 1922: Vitamin E (Tocopherol) Wheat germ oil, unrefined vegetable oils 1929: Vitamin K 1 (Phylloquinone) Leaf vegetables: 1931: Vitamin B 5 (Pantothenic ...
These include DL-alpha tocopheryl acetate, a synthetic form of vitamin E derived as a waste product from the petrochemical industry; a synthetic form of vitamin B1 called thiamine mononitrate ...
Vitamin B 1 analogues are analogues of vitamin B 1, thiamine. They typically have improved bioavailability relative to thiamine itself, and are used to treat conditions caused by vitamin B 1 deficiency. These conditions include beriberi, Korsakoff's syndrome, Wernicke's encephalopathy and diabetic neuropathy.
Fursultiamine (INN; chemical name thiamine tetrahydrofurfuryl disulfide or TTFD; brand names Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor, Lipothiamine) is a medication and vitamin used to treat thiamine deficiency. Chemically, it is a disulfide derivative of thiamine and is similar in structure to allithiamine. [1]
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