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Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver.. It can be a side-effect, but hepatotoxins are also found naturally, such as microcystins and pyrrolizidine alkaloids, or in laboratory environments, such as carbon tetrachloride, or far more pervasively in the form of ethanol (drinking alcohol).
Upload file; Search. Search. Appearance. Donate; Create account; ... Drugs and other substances that have been associated with significant hepatotoxicity (liver ...
Branded version withdrawn by originator in several countries in 2007 for hepatotoxicity. Generic versions available. Still available in US market. Nialamide: 1974 UK, US Hepatotoxicity, drug intereaction. [3] Nikethamide: 1988 multiple markets CNS Stimulation. [3] Nitrefazole: 1984 Germany Hepatic and hematologic toxicity. [3] Nomifensine: 1981 ...
Tolcapone has demonstrated significant liver toxicity (hepatotoxicity) [13] that limits the drug's utility. Entacapone is an alternative, largely since it has a more favorable toxicity profile. The hepatotoxicity can be related to elevated levels of transaminases , but studies have shown that minimal risk exists for those without preexisting ...
Users of Alli and Xenical, beware -- the diet drugs may cause liver failure, according to the U.S. Food and Drug Administration. In a statement released on May 26, the government agency said ...
"Even a small amount can be fatal, as it can cause respiratory failure," he said. Carfentanil can sometimes be in the form of "pressed pills" that resemble prescription medications, the expert said.
The reasoning so far is simple: Just as a GLP-1 can make eating food less enjoyable because it modulates your brain’s pleasure and reward center, doctors say that it could impact how you feel ...