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A mitogenic growth factor activity was found in pituitary extracts by Armelin in 1973 [14] and further work by Gospodarowicz as reported in 1974 described a more defined isolation of proteins from cow brain extract which, when tested in a bioassay that caused fibroblasts to proliferate, led these investigators to apply the name "fibroblast ...
Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated acidic FGF, Heparin-binding growth factor-1, and Endothelial cell growth factor-1. [7] Gene sequencing revealed that this group was actually the same growth factor and that FGF1 was a member of a family of FGF proteins.
It is also often used as a substrate in cell culture experiments. The presence of laminin-1 can influence how the growth cone responds to other cues. For example, growth cones are repelled by netrin when grown on laminin-111 but are attracted to netrin when grown on fibronectin.
Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. [ 5 ] [ 6 ] It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins , themselves a family of closely related molecules.
Fibroblast growth factor 18 (FGF-18) is a protein that is encoded by the FGF18 gene in humans. [ 5 ] [ 6 ] [ 7 ] The protein was first discovered in 1998, when two newly-identified murine genes Fgf17 and Fgf18 were described and confirmed as being closely related by sequence homology to Fgf8. [ 8 ]
Unlike other fibroblast cell types, dermal fibroblasts are far less likely to change into other cell types. [4] For example, when a dermal fibroblast and a corneal fibroblasts are placed in the same concentrations of fibroblast growth factor, dermal fibroblast will not differentiate or change.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified ...
14177 Ensembl ENSG00000111241 ENSMUSG00000000183 UniProt P10767 P21658 RefSeq (mRNA) NM_020996 NM_010204 RefSeq (protein) NP_066276 NP_034334 Location (UCSC) Chr 12: 4.43 – 4.45 Mb Chr 6: 126.99 – 127.01 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene. The protein encoded by this gene is a member ...
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