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Furthermore, after absorption from the gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to the digestive activity of the stomach and intestines, the oral route is unsuitable for certain substances, such as salvinorin A .
Antimicrobial action: Saliva can prevent microbial growth based on the elements it contains. For example, lactoferrin in saliva binds naturally with iron. Since iron is a major component of bacterial cell walls, removal of iron breaks down the cell wall, which in turn breaks down the bacterium.
It also is slow growing large painless and occurs mostly in the tongue. Congenital epulis: These are also known as congenital granular cell tumours (but not related to granular cell tumours), and occur mostly on the upper gum, the maxillary alveolar ridge, of newborns, predominantly females. Rarely, they occur elsewhere, usually the tongue.
It consists of one or more layers of epithelial cells overlying a layer of loose connective tissue. It is mostly of endodermal origin and is continuous with the skin at body openings such as the eyes , eyelids , ears , inside the nose , inside the mouth , lips , the genital areas , the urethral opening and the anus .
Saliva on a baby's lips. Saliva (commonly referred to as spit or drool) is an extracellular fluid produced and secreted by salivary glands in the mouth.In humans, saliva is around 99% water, plus electrolytes, mucus, white blood cells, epithelial cells (from which DNA can be extracted), enzymes (such as lipase and amylase), and antimicrobial agents (such as secretory IgA, and lysozymes).
The floor is formed by the mylohyoid muscles and is occupied mainly by the anterior two-thirds of the tongue. A mucous membrane – the oral mucosa, lines the sides and under surface of the tongue to the gums, and lines the inner aspect of the jaw . It receives secretions from the submandibular and sublingual salivary glands.
Further, because the secretory cells are of both serous and mucous types, the submandibular gland is a mixed gland, and though most of the cells are serous, the exudate is chiefly mucous. It has long striated ducts and short intercalated ducts. [7] The secretory acinar cells of the submandibular gland have distinct functions.
The sublingual gland (glandula sublingualis) is a seromucous polystomatic exocrine gland.Located underneath the oral diaphragm (diaphragma oris), the sublingual gland is the smallest and most diffuse of the three major salivary glands of the oral cavity, with the other two being the submandibular and parotid.