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Furthermore, after absorption from the gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to the digestive activity of the stomach and intestines, the oral route is unsuitable for certain substances, such as salvinorin A .
Sublingual administration is when medication is placed under the tongue to be absorbed by the body. The word "sublingual" means "under the tongue." Buccal administration involves placement of the drug between the gums and the cheek. These medications can come in the form of tablets, films, or sprays.
It then passes between the sublingual gland and the genioglossus and opens by a narrow opening on the summit of a small papilla (the "sublingual caruncle") at the side of the frenulum of the tongue. It lies superior to lingual and hypoglossal nerves .
Around 800 to 1,000 minor salivary glands are located throughout the oral cavity within the submucosa [12] of the oral mucosa in the tissue of the buccal, labial, and lingual mucosa, the soft palate, the lateral parts of the hard palate, and the floor of the mouth or between muscle fibers of the tongue. [13]
Human submandibular gland. At the right is a group of mucous acini, at the left a group of serous acini. Lobes contain smaller lobules, which contain adenomeres, the secretory units of the gland. Each adenomere contains one or more acini, or alveoli, which are small clusters of cells that secrete their products into a duct.
Thin-film drug delivery uses a dissolving film or oral drug strip to administer drugs via absorption in the mouth (buccally or sublingually) and/or via the small intestines (enterically). A film is prepared using hydrophilic polymers that rapidly dissolves on the tongue or buccal cavity, delivering the drug to the systemic circulation via ...
The fimbriated fold of tongue, also plica fimbriata, is a slight fold of the mucous membrane on the underside of the tongue which runs laterally on either side of the frenulum. The free edge of the fimbriated fold occasionally exhibits a series of fringe-like processes. (Fimbria is Latin for fringe).
The thin strip of tissue that runs vertically from the floor of the mouth to the undersurface of the tongue is called the lingual frenulum. It tends to limit the movement of the tongue, and in some people, it is so short that it actually interferes with speaking. A hump of tissue near the base of the tongue houses a series of saliva gland ducts.