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Side effects can include nausea, headache, blood clots, breast pain, depression, and liver problems. [2] Use is not recommended during pregnancy, the initial three weeks after childbirth, and in those at high risk of blood clots. [2] [4] It, however, may be started immediately after a miscarriage or abortion. [4]
NETE is a prodrug of norethisterone in the body. [13] Upon reaching circulation, it is rapidly converted into norethisterone by esterases.Hence, as a prodrug of norethisterone, NETE has essentially the same effects as norethisterone, acting as a potent progestogen with additional weak androgenic and estrogenic activity (the latter via its metabolite ethinylestradiol). [14]
Side effects of norethisterone include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth. [16] [17] Norethisterone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.
List of side effects of estradiol which may occur as a result of its use or have been associated with estrogen and/or progestogen therapy includes: [1] [2]. Gynecological: changes in vaginal bleeding, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis including vaginal candidiasis, changes in cervical secretion and cervical ectropion, ovarian cancer, endometrial hyperplasia ...
Norethisterone acetate (NETA), also known as norethindrone acetate and sold under the brand name Primolut-Nor among others, is a progestin medication which is used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders.
Side effects of mestranol include nausea, breast tension, edema, and breakthrough bleeding among others. [10] It is an estrogen, or an agonist of the estrogen receptors, the biological target of estrogens like estradiol. [11] Mestranol is a prodrug of ethinylestradiol in the body. [11]
Estradiol is an estrogen, or an agonist of the estrogen receptors, whereas norethisterone acetate is a progestin (synthetic progestogen), or an agonist of the progesterone receptors. [14] Relugolix suppresses ovarian sex hormone production , whereas estradiol and norethisterone acetate provide hormonal add-back to reduce hypogonadal and ...
The use of COCP is dependent on desirable effects and risk of adverse events with progestin component and dose of estrogen and progestin component. Estrogen component: Estradiol, Ethinylestradiol, or Estetrol; First-generation progestin: Norethindrone acetate, Ethynodiol diacetate, Lynestrenol, Norethynodrel
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