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Potassium-sparing diuretics or antikaliuretics [1] refer to drugs that cause diuresis without causing potassium loss in the urine. [2] They are typically used as an adjunct in management of hypertension , cirrhosis , and congestive heart failure . [ 3 ]
The thiazides and potassium-sparing diuretics are considered to be calcium-sparing diuretics. [6] The thiazides cause a net decrease in calcium lost in urine. [7] The potassium-sparing diuretics cause a net increase in calcium lost in urine, but the increase is much smaller than the increase associated with other diuretic classes. [7]
For potassium-sparing diuretics, its common side effects include hyponatremia, hyperkalemia, metabolic acidosis and sexual dysfunction specifically for spironolactone. [ 4 ] [ 5 ] The use of diuretics should be avoided in patients with severe dehydration, anuria (absence of urine production). [ 4 ]
Thiazide diuretics inhibit this receptor, causing the body to release NaCl and water into the lumen, thereby increasing the amount of urine produced each day. [6] An example of a molecule that is chemically a thiazide but not used as a diuretic is methylchloroisothiazolinone , often found as an antimicrobial in cosmetics.
Canrenone is an active metabolite of spironolactone, canrenoic acid, and potassium canrenoate, and is considered to be partially responsible for their effects. [9] It has been found to have approximately 10 to 25% of the potassium-sparing diuretic effect of spironolactone, [ 16 ] whereas another metabolite, 7α-thiomethylspironolactone (7α-TMS ...
Pages in category "Potassium-sparing diuretics" The following 8 pages are in this category, out of 8 total. This list may not reflect recent changes. A. Amiloride; B.
Kidneys are important for regulating blood pressure and filtering waste products from the bloodstream; managing urine excretion to prevent dehydration; and regulating levels of electrolytes and ...
Hence, aldosterone antagonists are potassium (K +) sparing diuretics. The medication has a slightly delayed onset of action , and so it takes several days for diuresis to occur since the MR is a nuclear receptor which works through regulating gene transcription and gene expression .
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