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Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is taken orally or intravenously for rheumatoid arthritis , psoriasis , Crohn's disease , nephrotic syndrome , eczema , and in organ transplants to prevent rejection .
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances , both toxic chemicals and medications , on kidney function . [ 1 ] There are various forms, [ 2 ] and some drugs may affect kidney function in more than one way.
Ciclosporin (cyclosporine, Neoral): Blood levels of ciclosporin are increased if taken with grapefruit juice, orange juice, or apple juice. [12] A plausible mechanism involves the combined inhibition of enteric CYP3A4 and MDR1, which potentially leads to serious adverse events (e.g., nephrotoxicity).
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Ciclosporin is a cyclic polypeptide that has been used widely as an orally-available immunosuppressant. [1] It was originally used to prevent transplant rejection of solid organs but has also found use as an orally administered agent to treat psoriasis, [2] rheumatoid arthritis, [3] dry eye [4] and other auto-immune related conditions.
Police say Wolfe was found dead from multiple gunshot wounds in an apartment in North Las Vegas, Nev., on Dec. 21, according to reports from the Las Vegas Review-Journal, KSNV and Fox 5.
Odyssey entered into a “corporate integrity agreement” with the federal government and installed a “first of its kind clinical review protocol” to ensure that such abuses did not happen again, the company said in a press release. “We are pleased to have permanently resolved these matters with the federal government,” Odyssey said.
Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed . Find sources: "Immunosuppressive drug" – news · newspapers · books · scholar · JSTOR ( February 2022 )
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