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Grapefruit–drug interactions that affect the pre-systemic metabolism (i.e., the metabolism that occurs before the drug enters the blood) of drugs have a different duration of action than interactions that work by other mechanisms, such as on absorption, discussed below.
For example, when the blood pressure drug felodipine is taken with grapefruit juice rather than water, levels of the medication in the blood can more than double and result in headache, irregular ...
Important: If you're taking statins or medications for conditions like high blood pressure, cholesterol, heart arrhythmia, organ transplants, or allergies, it can be dangerous to eat grapefruit ...
When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds:
The Mayo Clinic has disavowed the grapefruit diet. [4] Novelist Fannie Hurst was a notable devotee of the diet. [5] It was re-popularized in the 1980s and nicknamed the "10-day, 10-pounds-off diet". [6] The idea that grapefruit eaten before a meal acts as a "catalyst" to burn body fat has no evidence from biochemistry. [6]
A single glass of grapefruit juice can interfere with your body's ability to break down a medication. Here's how to protect your health.
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Grapefruit can increase the amount of Cialis in your bloodstream. CYP3A4 (an enzyme in your intestine) is responsible for the metabolism of many drugs, including Cialis. Grapefruit can inhibit CYP3A4.