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Folate deficiency, also known as vitamin B 9 deficiency, is a low level of folate and derivatives in the body. [1] This may result in megaloblastic anemia in which red blood cells become abnormally large, and folate deficiency anemia is the term given for this medical condition. [ 3 ]
The 2013–2014 survey reported that for adults ages 20 years and older, men consumed an average of 249 μg/day folate from food plus 207 μg/day of folic acid from consumption of fortified foods, for a combined total of 601 μg/day of dietary folate equivalents (DFEs because each microgram of folic acid counts as 1.7 μg of food folate).
Folinic acid is a metabolically active form of folate that can be easily introduced into the folate cycle. A typical dose that is administered to children is 0.5–1 mg/kg daily, but the dose can be increased depending on the severity of symptoms and the age of the child.
(Folic acid/Folate) – Serum: Age > 1 year: 3.0 [126] 16 [126] 5 [127] ng/mL or μg/L 6.8 [128] 36 [128] 11 [128] nmol/L Vitamin B 9 (Folic acid/Folate) – Red blood cells: 200 [126] 600 [126] ng/mL or μg/L 450 [128] 1400 [128] nmol/L Pregnant: 400 [126] ng/mL or μg/L 900 [126] nmol/L Vitamin B 12 (Cobalamin) 130, [129] 160 [130] 700, [129 ...
Correction of the systemic folate deficiency, with the normalization of folate blood levels, is easily achieved with high doses of oral folates or much smaller doses of parenteral folate. [1] [6] [7] [8] This will rapidly correct the anemia, immune deficiency and GI signs. The challenge is to achieve adequate treatment of the neurological ...
[28] [29] A diet rich in natural folate (350 μg/d) can show as much increase in plasma folate as taking low levels of folic acid (250 μg/d) in individuals [30] However a comparison of general population outcomes across many countries with different approaches to increasing folate consumption has found that only general food fortification with ...
But if further studies confirm folic acid — which is inexpensive and widely available — as a suicide prevention tool, “it will be significant for the patients that have low folate levels ...
Victor Herbert (February 22, 1927 – November 19, 2002) [1] was an American hematologist who did ground-breaking work on folate and how its deficiency led to megaloblastic anemia and was a proponent of accurate and responsible nutrition information.
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