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Pregabalin, sold under the brand name Lyrica among others, is an anticonvulsant, analgesic, and anxiolytic amino acid medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless legs syndrome, opioid withdrawal, and generalized anxiety disorder (GAD). [13] [17] [18] Pregabalin also has antiallodynic properties.
However, food has been found to substantially delay the absorption of pregabalin and to significantly reduce peak levels without affecting the bioavailability of the drug; T max values for pregabalin of 0.6 hours in a fasted state and 3.2 hours in a fed state (5-fold difference), and the C max is reduced by 25–31% in a fed versus fasted state ...
Post-dural-puncture headache (PDPH) is a complication of puncture of the dura mater (one of the membranes around the brain and spinal cord). [3] The headache is severe and described as "searing and spreading like hot metal", involving the back and front of the head and spreading to the neck and shoulders, sometimes involving neck stiffness.
Lyrica may cause suicidal thoughts or behavior. Call 911 or your local emergency number if you experience changes in your mood, worsening depression, or thoughts of harming yourself.
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A Novo Nordisk-funded 2021 study looked at almost 2,000 adults with excess body weight or obesity without diabetes. Participants took once-weekly 2.4-milligram (mg) semaglutide injections or a ...
The effectiveness of pregabalin and its older relative gabapentin against pain syndromes of this kind (which tend to respond poorly to other analgesic drugs) has led to their widespread use, and these drugs have subsequently been found to be useful for many other medical applications, including as anticonvulsants, muscle relaxants, anxiolytics ...
It does not bind to blood cells. [2] The drug is known to cross the placental barrier. [2] Etifoxine is metabolized in the liver into several metabolites. [5] One of these metabolites, diethyletifoxine, is pharmacologically active. [5] The elimination half-life of etifoxine is 6 hours and of diethyletifoxine is almost 20 hours. [5]
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