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The macrolide ring is the lactone (cyclic ester) at upper left. Clarithromycin Roxithromycin. Macrolides are a class of mostly natural products with a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered.
Ketolide antibiotics (4 P) Pages in category "Macrolide antibiotics" The following 45 pages are in this category, out of 45 total.
Macrolide antibiotics (1 C, 45 P) Pages in category "Macrolides" The following 36 pages are in this category, out of 36 total.
The following is a list of antibiotics. The highest division between antibiotics is bactericidal and bacteriostatic. ... Macrolides(Bs) Azithromycin:
Azalides such as azithromycin are a class of macrolide antibiotics that were originally manufactured in response to the poor acid stability exhibited by original macrolides (erythromycin). [1] Following the clinical overuse of macrolides and azalides, ketolides have been developed to combat surfacing macrolide-azalide resistance among ...
Ketolides are antibiotics belonging to the macrolide group. Ketolides are derived from erythromycin by substituting the cladinose sugar with a keto-group and attaching a cyclic carbamate group in the lactone ring. [1] These modifications give ketolides much broader spectrum than other macrolides.
Desosamine is a 3-(dimethylamino)-3,4,6-trideoxyhexose found in certain macrolide antibiotics (contain a high level of microbial resistance) such as the commonly prescribed erythromycin, [1] [2] azithromycin, clarithroymcin, methymycin, narbomycin, oleandomycin, picromycin and roxithromycin.
Solithromycin (trade name Solithera) is a ketolide antibiotic undergoing clinical development for the treatment of community-acquired pneumonia [1] and other infections. [2] Solithromycin exhibits excellent in vitro activity against a broad spectrum of Gram-positive respiratory tract pathogens, [3] [4] including macrolide-resistant strains. [5]
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