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The Breslow Depth is a helpful measure of how far melanoma has invaded the body and the Clark Level is a staging system that describes the depth of melanoma as it grows in the skin.
Breslow's depth. In medicine, Breslow's depth was used as a prognostic factor in melanoma of the skin. It is a description of how deeply tumor cells have invaded. Currently, the standard Breslow's depth has been replaced by the AJCC depth, in the AJCC staging system of melanoma.
The Breslow thickness describes how thick the melanoma is. It measures in millimetres (mm) how far the melanoma cells have grown down into the layers of skin. There are 5 levels of tumour (T) thickness: Tis – the melanoma cells are only in the very top layer of the skin (epidermis) T1 – the melanoma is 1mm thick or less
The tumor’s Breslow depth is 1.1 to 2 millimeters (with ulceration) or 2.1 to 4 millimeters (without ulceration). As well, either it’s in 1 to 3 nearby lymph nodes, or, there’s satellite melanoma, in-transit melanoma, or both.
Tumor thickness: Known as Breslow thickness or Breslow depth, this is a significant factor in predicting how far a melanoma has advanced. In general, a thinner Breslow depth indicates a smaller chance that the tumor has spread and a better outlook for treatment success.
Note: It is important to note that while AJCC staging is used to help understand how far the melanoma has advanced through the body, other measures known as the Breslow Depth and the Clark Level relate to the specific melanoma biopsied, and the depth or thickness of that melanoma.
The thickness or depth of the melanoma is calculated by a pathologist looking at your melanoma under a microscope and is measured from the surface of your skin to the deepest point of the melanoma. It is measured in millimetres (mm). In general, melanomas less than 1mm in thickness have a very small chance of spreading.
The Clark scale and Breslow thickness describe how deeply the melanoma has gone into the skin. This is different to the number staging system that doctors also use. The Clark scale and Breslow thickness only look at the depth of melanoma cells in the skin. The number stages look at the melanoma depth, and also whether the melanoma has spread to ...
The main (primary) tumor(T): How deep has the cancer grown into the skin? Is the cancer ulcerated? Tumor thickness: The thickness of the melanoma is called the Breslow measurement. In general, melanomas less than 1 millimeter (mm) thick (about 1/25 of an inch) have a very small chance of spreading.
Breslow thickness/depth is the single most important prognostic factor for clinically localised primary melanoma. 1 Breslow thickness is measured from the top of the granular layer of the epidermis (or, if the surface is ulcerated, from the base of the ulcer) to the deepest invasive cell