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Frequency. 1 in 1,000,000. Stiff-person syndrome (SPS), also known as stiff-man syndrome, [1] is a rare neurological disorder of unclear cause characterized by progressive muscular rigidity and stiffness. The stiffness primarily affects the truncal muscles and is characterised by spasms, resulting in postural deformities.
The dawn phenomenon, sometimes called the dawn effect, is an observed increase in blood sugar (glucose) levels that takes place in the early-morning, often between 2 a.m. and 8 a.m. First described by Schmidt in 1981 as an increase of blood glucose or insulin demand occurring at dawn, [ 1 ] this naturally occurring phenomenon is frequently seen ...
She suddenly developed diabetes at age 35 — a condition that's commonly linked with stiff-person syndrome — but didn't have an explanation for why it had happened. By 2017, Galgani says she ...
The Mayo Clinic describes Stiff Person Syndrome as "a rare disorder of motor function characterized by involuntary stiffness of axial muscles and superimposed painful muscle spasms, which are ...
4.2 million (2019) [ 9 ] Diabetes mellitus, often known simply as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. [ 10 ][ 11 ] Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body becoming unresponsive to the hormone's effects. [ 12 ]
Diabetic cheiroarthropathy, also known as diabetic stiff hand syndrome or limited joint mobility syndrome, is a cutaneous condition characterized by waxy, thickened skin and limited joint mobility of the hands and fingers, leading to flexion contractures, a condition associated with diabetes mellitus [1]: 681 and it is observed in roughly 30% of diabetic patients with longstanding disease.
Type 2 diabetes makes up about 90% of cases of diabetes, with the other 10% due primarily to type 1 diabetesand gestational diabetes.[1] In type 1 diabetes, there is a lower total level of insulinto control blood glucose, due to an autoimmune-induced loss of insulin-producing beta cellsin the pancreas. [12][13]Diagnosis of diabetes is by blood ...
Anticholinergic drugs reduce gastric motility, prolonging the time drugs spend in the gastrointestinal tract. This impairment may lead to more metformin being absorbed than without the presence of an anticholinergic drug, thereby increasing the concentration of metformin in the plasma and increasing the risk for adverse effects.