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B cell activation: from immature B cell to plasma cell or memory B cell Basic B cell function: bind to an antigen, receive help from a cognate helper T cell, and differentiate into a plasma cell that secretes large numbers of antibodies. B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. [1]
In B cells, the function of IgD is to signal the B cells to be activated. By being activated, B cells are ready to take part in the defense of the body as part of the immune system. During B cell differentiation, IgM is the exclusive isotype expressed by immature B cells. IgD starts to be expressed when the B cell exits the bone marrow to ...
Transitional B cells that survive selection against autoreactivity develop eventually into naive B cells. [3] Given the fact that only a small fraction of immature B cells survive the transition to the mature naive stage, the transitional B cell compartment is widely believed to represent a key negative selection checkpoint for autoreactive B ...
Finally the dividing cells differentiate into effector cells, known as plasma cells (for B cells), cytotoxic T cells, and helper T cells. [ 1 ] Lymphoblasts can also refer to immature cells which typically differentiate to form mature lymphocytes . [ 2 ]
Most textbooks say that B Cells mature in the bone marrow but, generally, immature B cells migrate to the spleen for 'higher education' of some sort where they go through transitional stages before final maturation. (Medical Immunology, p. 136) B lymphocytes are identified by the presence of soluble immunoglobulin G (IgG). This is the most ...
For example, in the lymphoid cell, a partial rearrangement of the heavy-chain gene occurs which is followed by complete rearrangement of heavy-chain gene. Here at this stage, Pre-B cell, mμ heavy chain and surrogate light chain are formed. The final rearrangement of the light chain gene generates immature B cell and mIgM.
Immunoblasts are the most immature members of the protective cells involved in an immune response. Activated B cells may differentiate into memory cells or plasma cells, while activated T cells may differentiate into memory cells or effector cells that aid in the immune response.
This figure depicts the process of B cell selection in the bone marrow. Immature B cells in the bone marrow undergo negative selection when they bind self peptides. [2] Properly functioning B cell receptors recognize non-self antigen, or pathogen-associated molecular proteins . [1] Main outcomes of autoreactivity of BCRs [1] [2]