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The primary antidote to brodifacoum poisoning is immediate administration of vitamin K 1 (dosage for humans: initially slow intravenous injections of 10–25 mg repeated at 3–6 hours until normalisation of the prothrombin time; then 10 mg orally four times daily as a "maintenance dose"). It is an extremely effective antidote, provided the ...
Brodifacoum This molecule is a second-generation anticoagulant with a large 3-position substituent which causes it to be retained in fatty tissues for longer times than first-generation compounds and pharmaceuticals. (rodenticide) Bromadiolone (rodenticide) Coumatetralyl (rodenticide) Difenacoum (rodenticide) Flocoumafen (rodenticide)
Warning label on a tube of rat poison containing bromadiolone on a dike of the Scheldt river in Steendorp, Belgium. Bromadiolone is a potent anticoagulant rodenticide.It is a second-generation 4-hydroxycoumarin derivative and vitamin K antagonist, often called a "super-warfarin" for its added potency and tendency to accumulate in the liver of the poisoned organism.
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Brodifacoum takes a very long time to break down in soil and water and accumulates in the tissue of exposed animals for years. Consequently, there is a very high risk of by-kill: it is known to have killed at least 21 species of native birds, including kiwi, kākā, kākāriki and tūī. [76] It is also widely considered a very inhumane poison.
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Anticoagulants such as brodifacoum certainly can cause pain and suffering before death occurs, like if a blood vessel ruptures and leads to haemorrhage into a joint or in the cerebral cavity; however most of the poisoned rodents die rather calmly, after falling asleep from the blood loss. The bleeding itself is not caused by a trauma, but by a ...