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There is tentative evidence for flutamide in women; however, it is associated with relatively high rates of liver problems and strong recommendations have been made against its use. [14] [35] Like spironolactone, flutamide is typically only used by women. [36] Bicalutamide is another option for the treatment of female pattern hair loss.
Unlike spironolactone, bicalutamide has no antimineralocorticoid activity, [97] and for this reason, has no risk of hyperkalemia (which can, rarely/in severe cases, result in hospitalization or death) [112] or other antimineralocorticoid side effects such as urinary frequency, dehydration, hypotension, hyponatremia, metabolic acidosis, or ...
A 2009 review found that saw palmetto is the most popular botanically derived 5 alpha reductase (5aR) inhibitor. Another meta-analysis looked at both oral and topical saw palmetto.
[145] [146] [147] However, a 2017 hybrid systematic review found that the incidence of depression in women treated with spironolactone for acne was less than 1%. [64] Likewise, a 10-year observational study found that the incidence of depression in 196 transgender women taking high-dose spironolactone in combination with an estrogen was less ...
Key Ingredients: 2% minoxidil solution, biotin gummies, shampoo with salicylic acid, saw palmetto, and pumpkin seed oil | Best for: All hair types experiencing thinning and loss, and those that ...
It is commonly seen in women with PCOS, and also occurs in women with intersex conditions like congenital adrenal hyperplasia. [13] Hyperandrogenism is associated with virilization – that is, the development of masculine secondary sexual characteristics like male-pattern facial and body hair growth (or hirsutism), voice deepening , increased ...
[152] [148] [161] For these reasons, bicalutamide has replaced spironolactone in the treatment of the condition. [100]: 2139 For comparison to bicalutamide, a higher dosage of spironolactone of 5 mg/kg (or about 100 to 150 mg in boys that are 20 to 30 kg or 45 to 65 lbs) once daily is recommended for use in male peripheral precocious puberty.
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