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Rift Valley fever (RVF) is a viral disease of humans and livestock that can cause mild to severe symptoms. The mild symptoms may include: fever , muscle pains , and headaches which often last for up to a week.
Rift Valley fever virus Rift Valley fever: 2–6 days Fever, headache, myalgia and liver abnormalities 4–7 days Hemorrhagic fever, meningoencephalitis 1% in humans; in pregnant livestock, 100% fatality rate for fetuses Culex tritaeniorhynchus and Aedes vexans: Micropteropus pusillus and Hipposideros abae: Eastern, Southern, and Western Africa Yes
Since the flock had been vaccinated 2 weeks before for protection against the Rift Valley virus, [6] the possibility of a "new" disease was not put into consideration; the vaccine was assumed to be the culprit. Although they both share similarities, the WSL virus was isolated as distinct from the Rift Valley virus after the examination of a ...
There is no licensed vaccine for bunyaviruses. As precautions Cache Valley virus and Hantavirus research are conducted in BSL-2 (or higher), Rift Valley Fever virus research is conducted in BSL-3 (or higher), Congo-Crimean Hemorrhagic Fever virus research is conducted in BSL-4 laboratories. [citation needed]
the Rift Valley fever (RVF) virus from the genus Phlebovirus (Phenuiviridae). The family Filoviridae (order Mononegavirales ) includes Ebola virus and Marburg virus . The family Flaviviridae (order Amarillovirales ) includes dengue , yellow fever , and two viruses in the tick-borne encephalitis group that cause VHF: Omsk hemorrhagic fever virus ...
NAMRU-3 through a collaboration with the WHO in the early 1970s was instrumental in developing typhoid and Group A Meningococcal meningitis vaccines. In 2000, NAMRU-3 successfully investigated the first outbreak of Rift Valley fever outside Africa in Yemen.
Additionally, the fusion of Rift Valley fever virus (RVFV) in late endosomes is inhibited by the interferon-induced transmembrane proteins 2 and 3 (IFITIM2 and IFITIM3). Third, the viral and endosomal membranes are fused to allow for the release of the viral ribonucleoprotein complexes into the cytoplasm (Also the site of viral transcription ...
In experiments in animals favipiravir has shown activity against West Nile virus, yellow fever virus, foot-and-mouth disease virus as well as other flaviviruses, arenaviruses, bunyaviruses and alphaviruses. [53] Activity against enteroviruses [54] and Rift Valley fever virus has also been demonstrated. [55]