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Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V 2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
Tolvaptan phosphate is a drug used for the treatment of cardiac edema. It is a prodrug of tolvaptan, [1] [2] formulated as the salt tolvaptan sodium phosphate, for intravenous administration. Tolvaptan phosphate is converted into the active drug tolvaptan in the human body following administration.
Typical pharmacodynamic effects of the drug are an increase in net fluid loss, increase in urine output, and decrease in the osmolality of urine. Conivaptan inhibits its own metabolism in the body, displaying non-linear pharmacokinetics. About 99% of conivaptan found is bound to human plasma proteins over the range of 10 ng/mL to 1000 ng/mL.
While most patients take GLP-1 drugs with few or no serious side effects, it's common to experience at least mild gastrointestinal issues like nausea, vomiting, stomach pain, constipation, and ...
“Over a year-and-a-half, this certainly could be because she is using Ozempic, or could also be because she is taking care of herself, going to the gym, and eating well. “Over that time you ...
Fear isn’t rare—we all have things we’re scared of, whether that’s heights (hey!), spiders, open water, snakes, or, well, anything and everything. A phobia you may have heard a little less ...
Many patients will not develop these side effects, although there is still a significant possibility of risks associated with Antipsychotic usage. The percentage of patients affected by side effects like Tardive dyskinesia is significantly high and estimated to be a 20-50% prevalence. [1] [2]
Image credits: VastCoconut2609 On the other hand, good news has the power to boost our happiness and overall well-being, says Ruiz-McPherson. And the better our mood, the lower our stress levels.