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Liver regeneration is the process by which the liver is able to replace damaged or lost liver tissue. The liver is the only visceral organ with the capacity to regenerate. [ 1 ] [ 2 ] The liver can regenerate after partial hepatectomy or injury due to hepatotoxic agents such as certain medications, toxins, or chemicals. [ 3 ]
Growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae), also known as GFER, or Hepatopoietin is a protein which in humans is encoded by the GFER gene. This gene is also known as essential for respiration and vegatative growth, augmenter of liver regeneration, and growth factor of Erv1-like/Hepatic regenerative stimulation ...
1361 56373 Ensembl ENSG00000080618 ENSMUSG00000021999 UniProt Q96IY4 Q9JHH6 RefSeq (mRNA) NM_016413 NM_001278541 NM_001872 NM_019775 RefSeq (protein) NP_001265470 NP_001863 NP_062749 Location (UCSC) Chr 13: 46.05 – 46.11 Mb Chr 14: 75.48 – 75.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma ...
A liver support system or diachysis is a type of therapeutic device to assist in performing the functions of the liver. Such systems focus either on removing the accumulating toxins (liver dialysis), or providing additional replacement of the metabolic functions of the liver through the inclusion of hepatocytes to the device (bioartificial liver device).
Spontaneous regeneration occurs in the human body naturally. The most recognised example of this is the regeneration of the liver, [16] which can regenerate up to two thirds of its mass when injured by surgical removal, ischaemia or after exposure to harmful toxins. [16] (Figure 2) Figure 2: Mechanism of liver regeneration in adult humans
3082 15234 Ensembl ENSG00000019991 ENSMUSG00000028864 UniProt P14210 Q08048 RefSeq (mRNA) NM_000601 NM_001010931 NM_001010932 NM_001010933 NM_001010934 NM_010427 NM_001289458 NM_001289459 NM_001289460 NM_001289461 RefSeq (protein) NP_000592 NP_001010931 NP_001010932 NP_001010933 NP_001010934 NP_001276387 NP_001276388 NP_001276389 NP_001276390 NP_034557 Location (UCSC) Chr 7: 81.7 – 81.77 Mb ...
Nodular regenerative hyperplasia (NRH) is a rare liver disease, characterised by the growth of nodules within the liver, resulting in liver hyperplasia.While in many cases it is asymptomatic and thus goes undetected – or is only discovered incidentally while investigating some other medical condition – in some people it results in non-cirrhotic portal hypertension (NCPH).
Nevertheless, the liver is the only tissue in which a significant number of different HNFs are expressed at the same time. In addition, there are a number of genes which contain multiple promoter and enhancer regions each regulated by a different HNF. Furthermore, efficient expression of these genes require synergistic activation by multiple HNFs.