Search results
Results from the WOW.Com Content Network
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin ...
AOH1996 was created to target a post-translationally modified isoform of PCNA, termed caPCNA, which is preferentially found in cancer cells. PCNA is crucial in the body for DNA repair , but targeting it is difficult because of its role in healthy cells.
From an initialism: This is a redirect from an initialism to a related topic, such as the expansion of the initialism.. Use {{R from acronym}} instead for abbreviations that are pronounced as words, such as NATO and RADAR.
PCNA, [11] [14] [15] RB1. [16] and; G9A [17] DNMT1 is highly transcribed during the S phase of the cell cycle when it is required for methylation of the newly generated hemimethylated sites on daughter DNA strands. [18] Its interaction with PCNA and UHRF1 has been implicated in localizing it to the replication fork. [19]
The Communist Party of Albania (Albanian: Partia Komuniste e Shqipërisë, PKSh) is an anti-revisionist Marxist–Leninist communist party in Albania.The party was formed in 1991, [1] [2] as a split from the Party of Labour of Albania which converted itself into the Socialist Party of Albania.
The Albanian Wikipedia (Albanian: Wikipedia Shqip) is the Albanian language edition of Wikipedia started on 12 October 2003. As of 15 January 2025, the Wikipedia has 101,316 articles and is the 73rd-largest Wikipedia.
The mission of the Sigurimi was to prevent counterrevolutions and to suppress opposition to the existing political system. Although groups of Albanian émigrés sought Western support for their efforts to overthrow the Communist government in the late 1940s and early 1950s, they quickly ceased to be a credible threat because of the effectiveness of the Sigurimi.
The Council is responsible to the Parliament of Albania.The Parliament may choose to pass a motion of censure forcing the Council of Ministers to resign. This has the effect of forcing the Government to be composed of members from the majority political party in the Assembly or to be allied to the majority in a coalition.