Search results
Results from the WOW.Com Content Network
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin ...
AOH1996 is an experimental anticancer medication which acts as a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) and is in Phase I clinical trials at City of Hope as of August 2023 for the treatment of solid tumors. [1] [2] [3] [4]
Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!
Cryo-EM structure of the DNA-bound PolD–PCNA processive complex Structural basis for DNA binding by the PolD–PCNA complex. A DNA clamp, also known as a sliding clamp, is a protein complex that serves as a processivity-promoting factor in DNA replication.
In molecular biology and biochemistry, processivity is an enzyme's ability to catalyze "consecutive reactions without releasing its substrate". [1]For example, processivity is the average number of nucleotides added by a polymerase enzyme, such as DNA polymerase, per association event with the template strand.
RFC is involved in the maintenance of telomeres, nuclear DNA replication, mismatch repair, and nucleotide excision repair. In the presence of ATP, RFC can load Proliferating cell nuclear antigen [PCNA] and DNA polymerase to form DNA-RFC-PCNA-DNA polymerase, which elongates in the presence of deoxynucleotides [dNTPs] via the action of human single-stranded DNA-binding protein [HSSB].
DNA polymerase delta (DNA Pol δ) is an enzyme complex found in eukaryotes that is involved in DNA replication and repair.The DNA polymerase delta complex consists of 4 subunits: POLD1, POLD2, POLD3, and POLD4. [1]
Similarly, proliferating cell nuclear antigen (PCNA) is a protein associated with cell proliferation that is upregulated in proliferating cells, making it another useful antigen for immunostaining. [10] It is associated with DNA polymerase alpha, which is expressed throughout the phases of the cell cycle. The expression of PCNA also correlates ...