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Whereas the IC 50 value for a compound may vary between experiments depending on experimental conditions, (e.g. substrate and enzyme concentrations) the K i is an absolute value. K i is the inhibition constant for a drug; the concentration of competing ligand in a competition assay which would occupy 50% of the receptors if no ligand were present.
The PDBbind database is a comprehensive collection of experimentally measured binding affinity data (Kd, Ki, and IC50) for the protein-ligand complexes deposited in the Protein Data Bank (PDB). [ 1 ] [ 2 ] It thus provides a link between energetic and structural information of protein-ligand complexes, which is of great value to various studies ...
Ligand efficiency is a measurement of the binding energy per atom of a ligand to its binding partner, such as a receptor or enzyme. [1]Ligand efficiency is used in drug discovery research programs to assist in narrowing focus to lead compounds with optimal combinations of physicochemical properties and pharmacological properties.
These BASIC dialects are optimised for calculator use, combining the advantages of BASIC and keystroke programming. They have little in common with mainstream BASIC. [4] [5] [6] The version for the Ti-89 and subsequent is more fully featured, including the full set of string and character manipulation functions and statements in standard Basic.
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The Calculator in non-LTSC editions of Windows 10 is a Universal Windows Platform app. In contrast, Windows 10 LTSC (which does not include universal Windows apps) includes the traditional calculator, but which is now named win32calc.exe. Both calculators provide the features of the traditional calculator included with Windows 7 and Windows 8.x ...
GNOME Calculator, a software calculator. A software calculator is a calculator that has been implemented as a computer program, rather than as a physical hardware device. They are among the simpler interactive software tools, and, as such, they provide operations for the user to select one at a time. They can be used to perform any process that ...
On a single-step or immediate-execution calculator, the user presses a key for each operation, calculating all the intermediate results, before the final value is shown. [ 1 ] [ 2 ] [ 3 ] On an expression or formula calculator , one types in an expression and then presses a key, such as "=" or "Enter", to evaluate the expression.