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Pramipexole is a dopamine agonist of the non-ergoline class. [8] Pramipexole was approved for medical use in the United States in 1997. [8] It is available as a generic medication. [9] In 2022, it was the 193rd most commonly prescribed medication in the United States, with more than 2 million prescriptions. [10] [11]
Dexpramipexole is the (D)-enantiomer of pramipexole. Enantiopure dexpramipexole has essentially no dopamine agonist activity and shares no other pharmacologic similarity to pramipexole. [10] In contrast, pramipexole the (S)-enantiomer is a dopamine agonist and is an approved drug (Mirapex) used in Parkinson's disease.
Vyvanse (lisdexamfetamine) – a pro-drug stimulant used to treat attention deficit hyperactivity disorder and binge eating disorder; Vyvanse is converted into Dexedrine in vivo; Viibryd – an antidepressant of the serotonin modulator and stimulators class; Vivactil (protriptyline) an antidepressant also used in the treatment of nerve pain
Berotralstat, sold under the brand name Orladeyo, is a medication used to prevent attacks of hereditary angioedema (HAE) in people aged twelve years and older. [3] [5] [7] [8] [4]
Mevidalen (LY-3154207) is a dopaminergic drug which is under development for the treatment of Lewy body disease, including those with Parkinson's disease. [1] [2] [3 ...
Its ability to activate both D 1-like and D 2-like receptors is similar to the case of apomorphine (which notably has greater efficacy in the treatment of Parkinson's disease than D 2-like-selective agonists but has suboptimal pharmacokinetic properties) and pergolide but unlike pramipexole and ropinirole.
Fluphenazine, sold under the brand name Prolixin among others, is a high-potency typical antipsychotic medication. [2] It is used in the treatment of chronic psychoses such as schizophrenia, [2] [3] and appears to be about equal in effectiveness to low-potency antipsychotics like chlorpromazine. [4]
Pipamperone acts as an antagonist of the 5-HT 2A, [7] 5-HT 2B, [8] 5-HT 2C [9] D 2, [7] D 3, [10] D 4, [7] [11] α 1-adrenergic, [10] and α 2-adrenergic receptors. [10] It shows much higher affinity for the 5-HT 2A and D 4 receptors over the D 2 receptor (15-fold in the case of the D 4 receptor, and even higher in the case of the 5-HT 2A receptor), [7] [10] [12] being regarded as "highly ...
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261