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Lokivetmab, trade name Cytopoint, is a monoclonal antibody used to treat atopic dermatitis in dogs. [1] It acts against interleukin 31 (IL-31), [2] which is a cytokine involved in causing itchiness (pruritus). [2] Lokivetmab is administered by subcutaneous injection; each dose is effective for four to eight weeks. [3]
Oclacitinib, sold under the brand name Apoquel among others, is a veterinary medication used in the control of atopic dermatitis and pruritus from allergic dermatitis in dogs at least 12 months of age. [1] [4] Chemically, it is a synthetic cyclohexylamino pyrrolopyrimidine janus kinase inhibitor that is relatively selective for JAK1. [5]
Cytopoint [88] mab: veterinary: Canis lupus familiaris IL31: Y: clinical signs of atopic dermatitis in dogs [88] Lorvotuzumab mertansine: mab: humanized: CD56: cancer Lucatumumab [13] mab: human: CD40: multiple myeloma, non-Hodgkin's lymphoma, Hodgkin's lymphoma: Lulizumab pegol [6] mab: humanized: CD28: autoimmune diseases Lumiliximab [9] mab ...
The JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death, and tumor formation.
Checkpoint inhibitor therapy is a form of cancer immunotherapy.The therapy targets immune checkpoints, key regulators of the immune system that when stimulated can dampen the immune response to an immunologic stimulus.
Apoquel is a medication prescribed for pets — particularly dogs — to alleviate symptoms associated with allergic dermatitis, such as itching and inflammation. The FDA has not officially ...
Cytotoxicity is the quality of being toxic to cells.Examples of toxic agents are toxic metals, toxic chemicals, microbe neurotoxins, radiation particles and even specific neurotransmitters when the system is out of balance.
Anemia – a reduction of the red blood cells in the body.; Leukopenia – a deficiency of white blood cells, or leukocytes [1]; Neutropenia – a type of leukopenia, with a specific deficiency in neutrophils [2]