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Trimethylamine N-oxide (TMAO) is an organic compound with the formula (CH 3) 3 NO. It is in the class of amine oxides. Although the anhydrous compound is known, trimethylamine N-oxide is usually encountered as the dihydrate. Both the anhydrous and hydrated materials are white, water-soluble solids.
FMO3 is the primary enzyme in humans which catalyzes the N-oxidation of trimethylamine into trimethylamine N-oxide; [8] [10] FMO1 also does this, but to a much lesser extent than FMO3. [ 13 ] [ 14 ] Genetic deficiencies of the FMO3 enzyme cause primary trimethylaminuria , also known as "fish odor syndrome".
Trimethylamine enters the body via the consumption of certain foods and supplements: [citation needed] When food is consumed that contains TMA and/or TMAO (predominately seafood; saltwater fish, shellfish, seaweed and kelp). TMAO is converted by bacteria in the lower gastrointestinal tract (gut) into TMA.
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Trimethylamine (TMA) is an organic compound with the formula N(CH 3) 3. It is a trimethylated derivative of ammonia. TMA is widely used in industry. [5] [6] At higher concentrations it has an ammonia-like odor, and can cause necrosis of mucous membranes on contact. [7] At lower concentrations, it has a "fishy" odor, the odor associated with ...
General structure of an amine oxide. In chemistry, an amine oxide, also known as an amine N-oxide or simply N-oxide, is a chemical compound that has the chemical formula R 3 N + −O −. It contains a nitrogen-oxygen coordinate covalent bond with three additional hydrogen and/or substituent-groups attached to nitrogen.
2329 226564 Ensembl ENSG00000076258 ENSMUSG00000026692 UniProt P31512 Q8VHG0 RefSeq (mRNA) NM_002022 NM_144878 RefSeq (protein) NP_002013 NP_659127 Location (UCSC) Chr 1: 171.31 – 171.34 Mb Chr 1: 162.62 – 162.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dimethylaniline monooxygenase [N-oxide-forming] 4 is an enzyme in humans encoded by the FMO4 gene. Function Metabolic N ...
Trimethylamine N-oxide reductase has the EC number 1.7.2.3, and these components refer to the following enzyme classifications: EC 1 enzymes are oxidoreductase enzymes, where an oxidation reduction reaction occurs, and the substrate being oxidized is either an oxygen or hydrogen donor