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Colchicine is a light-sensitive compound, so needs to be stored in a dark bottle. Upon exposure to light, colchicine undergoes photoisomerization and transforms into structural isomers, called lumicolchicine. After this transformation, colchicine is no longer effective in its mechanistic binding to tubulin, so is not effective as a drug. [74]
While colchicine is not used to treat cancer in humans, it is commonly used to treat acute attacks of gout. [26] Colchicine is an anti-inflammatory drug that has been in continuous use for more than 3000 years. Colchicine is an oral drug, known to be used for treating acute gout and preventing acute attacks of familial Mediterranean fever (FMF).
Sometimes, an online pharmacy may not be located in a country that is claimed. For example, one study of drug shipments claiming to be from Canada revealed many of the drugs actually originated in several other countries and were often false medications. [6] Minors can order controlled substances without adult supervision.
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Probenecid with colchicine is a combination medication used to treat gout. Brand names include ColBenemid, Col-Probenecid, and Proben-C. [1] References
NoScript can force the browser to always use HTTPS when establishing connections to some sensitive sites, in order to prevent man-in-the-middle attacks. This behavior can be triggered either by the websites themselves, by sending the Strict Transport Security header, or configured by users for those websites that don't support Strict Transport Security yet.
In the countries of the UK, National Health Service (NHS) prescriptions are either free or have a fixed price per item; [39] a prescription may be issued so the patient does not have to purchase the item at commercial price. Some medical software requires a prescription. [40] Legislation may define certain equipment as "prescription devices". [41]
Oxycodone, sold under the brand name Roxicodone and OxyContin (which is the extended-release form) among others, is a semi-synthetic opioid used medically for the treatment of moderate to severe pain.
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