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Prediction of transmembrane helices to identify transmembrane proteins. [111] 2001 TMPred: The TMpred program makes a prediction of membrane-spanning regions and their orientation. The algorithm is based on the statistical analysis of TMbase, a database of naturally occurring transmembrane proteins (bio.tools entry) [112]
Constituent amino-acids can be analyzed to predict secondary, tertiary and quaternary protein structure. This list of protein structure prediction software summarizes notable used software tools in protein structure prediction, including homology modeling, protein threading, ab initio methods, secondary structure prediction, and transmembrane helix and signal peptide prediction.
First of all, SOSUI looks for α helices that are relatively easy to predict, taking into account the known helical potentials of the given amino acid sequence(AAS). The much more difficult task is to differentiate between the α helices in soluble proteins and the ones in transmembrane proteins, the α helix being a very common secondary structure pattern in proteins.
This causes the cross-prediction between them, which is a weakness of many transmembrane topology predictors. By predicting signal peptides and transmembrane helices simultaneously (Phobius [14]), the errors caused by cross-prediction are reduced and the performance is substantially increased. Another feature used to increase the accuracy of ...
Download as PDF; Printable version; ... Transmembrane protein 254 is a transmembrane protein that is encoded by the TMEM254 gene, ... Using various tools at ExPASy ...
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The aim is to build tools that can accurately predict the outcome of protein targeting in cells. Prediction of protein subcellular localization is an important component of bioinformatics based prediction of protein function and genome annotation, and it can aid the identification of drug targets.