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A basic helix–loop–helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors. [2][3][4][5] The word "basic" does not refer to complexity but to the chemistry of the motif because transcription factors in general contain basic amino acid residues in order to facilitate DNA ...
BHLHE41. " Basic helix-loop-helix family, member e41 ", or BHLHE41, is a gene that encodes a basic helix-loop-helix transcription factor repressor protein in various tissues of both humans and mice. [5][6][7][8] It is also known as DEC2, hDEC2, and SHARP1, and was previously known as " basic helix-loop-helix domain containing, class B, 3 ", or ...
Basic helix-loop-helix ARNT-like protein 1 or aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL), or brain and muscle ARNT-like 1 is a protein that in humans is encoded by the BMAL1 gene on chromosome 11, region p15.3. It's also known as MOP3, and, less commonly, bHLHe5, BMAL, BMAL1C, JAP3, PASD3, and TIC.
HIF1A. Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. [5][6][7] The Nobel Prize in Physiology or Medicine 2019 was awarded for the discovery of HIF. HIF1A is a basic helix-loop-helix PAS domain containing ...
[5] [6] HES1 is one of the seven members of the Hes gene family (HES1-7). Hes genes code nuclear proteins that suppress transcription. [7] This protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription.
The MYCN gene is a member of the MYC family of transcription factors and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA. [5] N-Myc is highly expressed in the fetal brain and is critical for normal brain development.
Oligodendrocyte transcription factor (OLIG2) is a basic helix-loop-helix (bHLH) transcription factor encoded by the OLIG2 gene. The protein is of 329 amino acids in length, 32 kDa in size and contains one basic helix-loop-helix DNA-binding domain. [5] It is one of the three members of the bHLH family. The other two members are OLIG1 and OLIG3.
20464 Ensembl ENSG00000112246 ENSMUSG00000019913 UniProt P81133 Q61045 RefSeq (mRNA) NM_005068 NM_001374769 NM_011376 RefSeq (protein) NP_005059 NP_001361698 NP_035506 Location (UCSC) Chr 6: 100.39 – 100.46 Mb Chr 10: 50.77 – 50.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Single-minded homolog 1, also known as class E basic helix-loop-helix protein 14 (bHLHe14), is a ...