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Metformin does not cause kidney damage by itself, however there is a risk of serious side effects if metformin is used when you have impaired renal function, Dr. Gupta notes.
Metformin is generally safe in people with mild to moderate chronic kidney disease, with a proportional reduction of metformin dose according to severity of estimated glomerular filtration rate (eGFR) and with periodic assessment of kidney function, (e.g., periodic plasma creatinine measurement). [93]
[27] [30] Medical imaging of the kidneys, generally by ultrasonography, is recommended as part of a differential diagnosis if there is suspicion of urinary tract obstruction, urinary tract infection, kidney stones or polycystic kidney disease. [31] Conformation kidney biopsy should only be performed if non-diabetic kidney disease is suspected.
The medication most commonly may cause stomach upset and symptoms such as diarrhea but in general is well tolerated and has a relatively low chance of causing hypoglycemia. [36] One rare (about 1% chance) but serious side affect of metformin is that it can cause lactic acidosis, usually in patients with poor kidney function. [36]
Another small study on people without diabetes who were overweight or had obesity found that those taking metformin lost between 5.6 and 6.5 percent of their body weight. In contrast, the control ...
The type 2 diabetes drug metformin helped slow aging across multiple organs, including the brain, kidneys, and the skin, a study in cynomolgus monkeys has shows. Common diabetes drug may help slow ...
For most patients, a GFR over 60 (mL/min)/(1.73 m 2) is adequate. But significant decline of the GFR from a previous test result can be an early indicator of kidney disease requiring medical intervention. The sooner kidney dysfunction is diagnosed and treated the greater odds of preserving remaining nephrons, and preventing the need for dialysis.
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