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Eli Lilly’s Mounjaro, cleared for type 2 diabetes and awaiting FDA approval for weight loss, targets both GLP-1 and a hormone called GIP, and has produced weight loss of 21 to 23%.
Weight-loss pills are a convenient, needle-free option for people who need help losing unwanted body weight. Typically, people can lose up to 3% to 12% of their body weight while taking one of these medications. Prescription-only pills that are FDA approved for weight loss are summarized below.
Prescription weight-loss drugs that you can use for more than 12 weeks, called long-term use, lead to major weight loss compared with an inactive treatment that doesn't use medicine, called a placebo.
Xenical (orlistat) can help you lose weight and keep it off. It belongs to a class of medications called lipase inhibitors. Orlistat reduces the amount of fat absorbed in the gut after eating. When taking it, no more than 30% of your calories should come from fat.
The newest prescription drugs approved to treat obesity are semaglutide (Wegovy) and tirzepatide (Zepbound). Other older medications include liraglutide (Saxenda), naltrexone- bupropion...
FDA-approved medications for obesity. Medications approved by the U.S. Food and Drug Administration (FDA) for the treatment of obesity work primarily by reducing appetite and increasing feelings of fullness. Currently approved medications include:
The newest weight loss drug approved by the FDA is Zepbound (tirzepatide), a dual GIP/GLP-1 (glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1) agonist. Zepbound was approved on Nov. 8, 2023 and is given as a once-weekly subcutaneous (under the skin) injection in adults.
Weight loss of 5% to 10% of your starting body weight may help improve your health by lowering blood sugar, blood pressure, and triglyceride levels. Losing weight also can improve some other health problems related to overweight and obesity, such as joint pain and sleep apnea.
Although older weight loss drugs, called Orlistat (Xenical® or Alli®), affect how much fat you absorb from food, largely based on the idea that fat intake causes obesity, most current anti-obesity medications target appetite regulation (that is, they make you feel fuller for longer, decrease your appetite, etc.).
The following medications, paired with healthy eating and regular physical activity, are first-line medical options and result in moderate weight loss as noted as a percentage of body weight (reported as the difference compared to percent weight loss observed in the placebo group).