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Lipoatrophia semicircularis, also known as semicircular lipoatrophy, [1] is a medical condition in humans, commonly known as ribbed thighs. It consists of a semicircular zone of atrophy of the subcutaneous fatty tissue located mostly on the front of the thighs. Skin and underlying muscles remains intact.
Lipoatrophy is most commonly seen in patients treated with thymidine analogues and other older HIV drug treatments such as the nucleoside reverse transcriptase inhibitors [NRTIs] [9] like zidovudine (AZT) and stavudine (d4T). [10] Other lipodystrophies manifest as lipid redistribution, with excess, or lack of, fat in various regions of the body ...
The study found increased thigh muscle volume improved lean body mass following 12 weeks of treatment in the BVS857 group compared to placebo. [11] However, eleven of eighteen patients were found to have an immune response against BVS857, with five patients developing neutralizing antibodies, posing a challenge for long-term treatment.
Lipoatrophy is the term describing the localized loss of fat tissue. This may occur as a result of subcutaneous injections of insulin in the treatment of diabetes , from the use of human growth hormone or from subcutaneous injections of copaxone used for the treatment of multiple sclerosis .
Muscle loss can be quantified with advanced imaging studies but this is not frequently pursued. Treatment depends on the underlying cause but will often include exercise and adequate nutrition. Anabolic agents may have some efficacy but are not often used due to side effects. There are multiple treatments and supplements under investigation but ...
CT shows muscle oedema with preserved tissue planes (non-contrast enhancing). MRI is the exam of choice and shows increased signal on T2 weighted images within areas of muscle oedema. Contrast enhancement is helpful but must be weighed against the risk of Nephrogenic Systemic Fibrosis as many diabetics have underlying chronic kidney disease .
Ozempic muscle loss can happen if you lose weight quickly. The same goes for Wegovy muscle loss, Mounjaro muscle loss, compounded semaglutide muscle loss, and other GLP-1 drugs that cause rapid ...
Acquired generalized lipodystrophy (AGL), also known as Lawrence syndrome [1] and Lawrence–Seip syndrome, [1] is a rare skin condition that appears during childhood or adolescence, characterized by fat loss affecting large areas of the body, particularly the face, arms, and legs.