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Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells , but also acts on haemopoietic progenitor cells and T cells .
Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene. [5] [6] [7]The protein encoded by this gene, belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing.
Hepatocyte growth factor receptor (HGF receptor) [5] [6] is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. [7] The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.
Insulin-like growth factor 1, a polypeptide protein hormone which plays an important role in childhood growth and continues to have anabolic effects in adults Thrombopoietin , a glycoprotein hormone that regulates the production of platelets by the bone marrow
9146 15239 Ensembl ENSG00000185359 ENSMUSG00000025793 UniProt O14964 Q99LI8 RefSeq (mRNA) NM_004712 NM_001159328 NM_008244 RefSeq (protein) NP_004703 NP_001152800 NP_032270 Location (UCSC) Chr 17: 81.68 – 81.7 Mb Chr 11: 120.36 – 120.37 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is ...
Levothyroxine is a frequently prescribed drug in the United States, particularly for older people, as lower thyroid function can be associated with aging. Questions remain over how appropriately ...
The regulatory mechanisms prepare hepatocytes to enter the cell cycle. The proliferation phase involves activation of various growth factors, including two factors that play a major role in liver regeneration, EGFR (epidermal growth factor receptor) and c-Met. During this phase, hepatocytes undergo a series of cell division cycles and expansion ...
Human hepatocyte growth factor (HGF) is an 80kD [1] pleiotropic protein that is endogenously produced by a variety of cell types from the mesenchymal cell lineage (such as cardiomyocytes and neurons). [4] It is produced and proteolytically cleaved to its active state in response to cellular injury or during apoptosis.
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