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The WHO classification of tumours of the central nervous system is a World Health Organization Blue Book that defines, describes and classifies tumours of the central nervous system (CNS). Currently, as of 2023, clinicians are using the 5th edition, which incorporates recent advances in molecular pathology. [ 1 ]
The concept of grading of the tumors of the central nervous system, agreeing for such the regulation of the "progressiveness" of these neoplasias (from benign and localized tumors to malignant and infiltrating tumors), dates back to 1926 and was introduced by P. Bailey and H. Cushing, [1] in the elaboration of what turned out the first systematic classification of gliomas.
Gliomas are further categorised according to their grade, which is determined by pathologic evaluation of the tumor. The neuropathological evaluation and diagnostics of brain tumor specimens is performed according to WHO Classification of Tumours of the Central Nervous System. [55] [56] Low-grade brain glioma in a 28-year-old male.
The 2007 WHO Classification of Tumors of the Central Nervous System [37] was the last classification mainly based on microscopy features. The new 2016 WHO Classification of Tumors of the Central Nervous System [38] was a paradigm shift: some of the tumors were defined also by their genetic composition as well as their cell morphology.
Diagnosis of diffuse glioma, with typical characteristics of oligodendroglioma at left. [ 9 ] In WHO 2021 CNS5 Classification, [ 10 ] oligodendroglioma is named "Oligodendroglioma, IDH-mutant, and 1p/19q-codeleted", and requires the presence of IDH1 or IDH2 mutations and the codeletion of chromosome 1p and 19q arms.
The WHO Classification of Tumours, more commonly known as the WHO Blue Books, is a series of books that classify tumours. They are compiled by expert consensus and published by the World Health Organization 's (WHO) International Agency for Research on Cancer (IARC).
A nervous system tumor is a tumor that arises within the nervous system, either the central nervous system (CNS) or the peripheral nervous system (PNS). [1] [2] Nervous system primary tumors include various types of brain tumor and spinal tumors, such as gliomas, and meningiomas (of the CNS), and schwannomas (of the PNS) and can be either benign or malignant.
Glioma - Symptoms and causes. "Glioblastoma Multiforme Treatment at Mayo Clinic." Mayo Clinic: Medical Treatment and Research Centers. Web. 07 Dec. 2009. Glioma - Symptoms and causes. "The new WHO Classification of Tumors affecting the Central Nervous System" by Stephen B. Tatter, M.D., Ph.D.; MGH Archived 2012-01-30 at the Wayback Machine
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