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  2. Spinal muscular atrophy - Wikipedia

    en.wikipedia.org/wiki/Spinal_muscular_atrophy

    Spinal muscular atrophy (SMA) is a rare neuromuscular disorder that results in the loss of motor neurons and progressive muscle wasting. [ 3 ] [ 4 ] [ 5 ] It is usually diagnosed in infancy or early childhood and if left untreated it is the most common genetic cause of infant death. [ 6 ]

  3. Denervation - Wikipedia

    en.wikipedia.org/wiki/Denervation

    This magnified image of type 2 muscle fibers shows denervation atrophy occurring at the white spaces at the top left and bottom center of the image. The white space represents a disruption of the nerve fibers, resulting in a loss of nerve supply to the muscle fibers. Denervation is any loss of nerve supply regardless of the cause.

  4. Spinal muscular atrophies - Wikipedia

    en.wikipedia.org/wiki/Spinal_muscular_atrophies

    Spinal muscular atrophies (SMAs) are a genetically and clinically heterogeneous group of rare debilitating disorders characterised by the degeneration of lower motor neurons (neuronal cells situated in the anterior horn of the spinal cord) and subsequent atrophy (wasting) of various muscle groups in the body. [1]

  5. Spinal cord injury - Wikipedia

    en.wikipedia.org/wiki/Spinal_cord_injury

    Complications can include muscle atrophy, loss of voluntary motor control, spasticity, pressure sores, infections, and breathing problems. In the majority of cases the damage results from physical trauma such as car accidents , gunshot wounds , falls , or sports injuries , but it can also result from nontraumatic causes such as infection ...

  6. X-linked spinal muscular atrophy type 2 - Wikipedia

    en.wikipedia.org/wiki/X-linked_spinal_muscular...

    Affected babies have general muscle weakness, weak cry and floppy limbs; consequently, the condition is usually apparent at or even before birth. Symptoms resemble the more severe forms of the more common spinal muscular atrophy (SMA); however, SMAX2 is caused by a different genetic defect and only genetic testing can correctly identify the ...

  7. Progressive muscular atrophy - Wikipedia

    en.wikipedia.org/wiki/Progressive_muscular_atrophy

    The importance of correctly recognizing progressive muscular atrophy as opposed to ALS is important for several reasons. The prognosis is a little better. A recent study found the 5-year survival rate in PMA to be 33% (vs 20% in ALS) and the 10-year survival rate to be 12% (vs 6% in ALS).

  8. Spinal muscular atrophy with lower extremity predominance 1

    en.wikipedia.org/wiki/Spinal_muscular_atrophy...

    Spinal muscular atrophy with lower extremity predominance 1 (SMALED1) is an extremely rare neuromuscular disorder of infants characterised by severe progressive muscle atrophy which is especially prominent in legs. [1]

  9. Spinal and bulbar muscular atrophy - Wikipedia

    en.wikipedia.org/wiki/Spinal_and_bulbar_muscular...

    Spinal and bulbar muscular atrophy (SBMA), popularly known as Kennedy's disease, is a rare, adult-onset, X-linked recessive lower motor neuron disease caused by trinucleotide CAG repeat expansions in exon 1 of the androgen receptor (AR) gene, which results in both loss of AR function and toxic gain of function.

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