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HSV asymptomatic shedding occurs at some time in most individuals infected with herpes. It can occur more than a week before or after a symptomatic recurrence in 50% of cases. [ 36 ] Virus enters into susceptible cells by entry receptors [ 37 ] such as nectin-1, HVEM and 3-O sulfated heparan sulfate. [ 38 ]
Most sexual transmissions of HSV-2 occur during periods of asymptomatic shedding. [10] Asymptomatic reactivation means that the virus causes atypical, subtle, or hard-to-notice symptoms that are not identified as an active herpes infection, so acquiring the virus is possible even if no active HSV blisters or sores are present.
A human with a viral disease can be contagious if they are shedding virus particles, even if they are unaware of doing so. Some viruses such as HSV-2 (which produces genital herpes) can cause asymptomatic shedding and therefore spread undetected from person to person, as no fever or other hints reveal the contagious nature of the host. [10]
A daily swab of the genital area was self-collected for Human alphaherpesvirus 2 detection by polymerase chain reaction, to compare the effect of valaciclovir versus placebo on asymptomatic viral shedding in immunocompetent, seropositive subjects without a history of symptomatic genital herpes infection. The study found that valaciclovir ...
Genital herpes can be spread by viral shedding prior to and following the formation of ulcers. The risk of spread between a couple is about 7.5% over a year (for unprotected sex). [ 6 ] The likelihood of transferring genital herpes from one person to another is decreased by external condom use by 50%, by internal condom by 50%, and refraining ...
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