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The total number of genes that contribute to eye color is unknown, but there are a few likely candidates. A study in Rotterdam (2009) found that it was possible to predict eye color with more than 90% accuracy for brown and blue using just six SNPs. [16] [17] In humans, eye color is a highly sexually dimorphic trait. [18]
The first retinal gene therapy to be approved by the FDA was Voretigene neparvovec in 2017, which treats Leber's congenital amaurosis, a genetic disorder that can lead to blindness. These treatments also use subretinal injections of AAV vector and are therefore foundational to research in gene therapy for color blindness. [2] [3]
Rarer genetic conditions causing color blindness include congenital blue–yellow color blindness (tritan type), blue cone monochromacy, and achromatopsia. Color blindness can also result from physical or chemical damage to the eye, the optic nerve, parts of the brain, or from medication toxicity. [2]
Eye color is determined by a few different genetic factors, the most important being OCA2. OCA2 produced melanocytes, or melanin producing cells. Melanin is the protein that creates skin, eye and ...
Privately held Alkeus Pharmaceuticals said on Wednesday its experimental therapy halted disease progression in patients with early stages of a genetic eye condition that leads to blindness. The ...
Most cases of heterochromia are the result of genetics, though sometimes, trauma or injury to the eye can disrupt the normal development of melanin in the iris—leading to changes in eye color.
This form of color blindness is sometimes referred to historically as daltonism after John Dalton, who had congenital red–green color blindness and was the first to scientifically study it. In other languages, daltonism is still used to describe red–green color blindness, but may also refer colloquially to color blindness in general.
This could mean (for example) eye color. Each genetic locus is always represented by two letters. So in the case of eye color, say "B = Brown eyes" and "b = green eyes". In this example, both parents have the genotype Bb. For the example of eye color, this would mean they both have brown eyes.
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