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2. Dipeptidyl peptidase-4 inhibitor - Wikipedia

   en.wikipedia.org/wiki/Dipeptidyl_peptidase-4...

   DPP-4 inhibitors and GLP-1. Inhibitors of dipeptidyl peptidase 4 (DPP-4 inhibitors or gliptins) are a class of oral hypoglycemics that block the enzyme dipeptidyl peptidase-4 (DPP-4). They can be used to treat diabetes mellitus type 2. The first agent of the class – sitagliptin – was approved by the FDA in 2006. [1]

3. 6 Common Side Effects from Taking a GLP-1 Medication ... - AOL

   www.aol.com/6-common-side-effects-taking...

   With nearly half of Americans saying weight loss is a goal for them, it’s no wonder that interest in GLP-1 medications has been on the rise. GLP-1 (short for glucagon-like peptide-1) medications ...

4. Glucagon-like peptide-1 - Wikipedia

   en.wikipedia.org/wiki/Glucagon-like_peptide-1

   To overcome this, GLP-1 receptor agonists and DPP-4 inhibitors have been developed to increase GLP-1 activity. As opposed to common treatment agents such as insulin and sulphonylureas, GLP-1-based treatment has been associated with weight loss and a lower risk of hypoglycemia, two important considerations for patients with type 2 diabetes.

5. Discovery and development of dipeptidyl peptidase-4 inhibitors

   en.wikipedia.org/wiki/Discovery_and_development...

   One of the first reported DPP-4 inhibitor was P32/98 from Merck. It used thiazolidide as the P1-substitute and was the first DPP-4 inhibitor that showed effects in both animals and humans but it was not developed to a market drug due to side effects. Another old inhibitor is DPP-728 from Novartis, where 2-cyanopyrrolidine is used as the P1 ...

6. Diabetes medication - Wikipedia

   en.wikipedia.org/wiki/Diabetes_medication

   GLP-1 analogs resulted in weight loss and had more gastrointestinal side-effects, while in general dipeptidyl peptidase-4 (DPP-4) inhibitors were weight-neutral and are associated with increased risk for infection and headache. Both classes appear to present an alternative to other antidiabetic drugs.

7. GLP-1 drugs like Wegovy are all the rage—but people are ...

   www.aol.com/finance/glp-1-drugs-wegovy-rage...

   Most patients taking GLP-1 drugs for weight management didn’t stay on their prescribed treatment for the minimum 12 weeks, meaning they were unlikely to attain clinically meaningful weight loss.

8. Vildagliptin - Wikipedia

   en.wikipedia.org/wiki/Vildagliptin

   Vildagliptin inhibits the inactivation of GLP-1 [2] [3] and GIP [3] by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the islets of Langerhans in the pancreas. The most common side effects include dizziness. [1]

9. GLP-1 Drugs Like Zepbound and Mounjaro May Help Reduce ... - AOL

   www.aol.com/lifestyle/glp-1-drugs-zepbound...

   In clinical trials, GLP-1 drug tirzepatide reduced sleep apnea events by as much as two-thirds over the course of 52 weeks in patients with obstructive sleep apnea. Patients taking a placebo ...