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Early-onset Alzheimer's disease (EOAD), also called younger-onset Alzheimer's disease (YOAD), [1] is Alzheimer's disease diagnosed before the age of 65. [2] It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases.
When the disease is caused by autosomal dominant variants, it is known as early onset familial Alzheimer's disease, which is rarer and has a faster rate of progression. [17] Less than 5% of sporadic Alzheimer's disease have an earlier onset, [17] and early-onset Alzheimer's is about 90% heritable.
[279] [280] Less than 1% of those with Alzheimer's have gene mutations that cause a much earlier development of the disease, around the age of 45, known as early-onset Alzheimer's disease. [281] More than 95% of people with Alzheimer's disease have the sporadic form (late onset, 80–90 years of age). [ 281 ]
One genetic variant associated with Alzheimer’s disease progression is presenilin 2 (PSEN2), which is correlated to an increased risk for early-onset familial Alzheimer’s disease (EOFAD ...
“Alzheimer’s disease has a long pre-symptomatic period; Alzheimer’s-related changes take place in the brain 10, 15, even 20 years before the onset of memory and thinking symptoms.
Alzheimer’s usually is a disease of people over age 65 and while simply getting older is the main risk, the APOE gene has long been known to play some role. It comes in three main varieties.
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