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Dermatofibrosarcoma protuberans (DFSP) [2] is a rare locally aggressive malignant cutaneous soft-tissue sarcoma. DFSP develops in the connective tissue cells in the middle layer of the skin (dermis). [3] Estimates of the overall occurrence of DFSP in the United States are 0.8 to 4.5 cases per million persons per year.
A dermatofibroma is associated with the dimple sign; by applying lateral pressure, there is a central depression of the dermatofibroma. Although typical dermatofibromas cause little or no discomfort, itching and tenderness can occur. Dermatofibromas can be found anywhere on the body, but most often they are found on the legs and arms. [5]
About 10 [13] to 15% [1] of individuals initially or subsequently present with metastases, [2] most commonly in the lung, less commonly in the regional lymph nodes draining the site of the primary dermal tumor, [13] or, rarely, in the liver, kidney, soft tissue sites outside of the primary dermal tumor's areas, [3] mediastinum, or brain.
They can grow in all organs, arising from mesenchyme tissue. The term " fibroblastic " or "fibromatous" is used to describe tumors of the fibrous connective tissue . When the term fibroma is used without modifier, it is usually considered benign , with the term fibrosarcoma reserved for malignant tumors.
Bcl-2: Basal cell carcinoma Primary cutaneous marginal zone lymphoma Diffuse large B-cell lymphoma leg type: Bcl-6: Primary cutaneous follicular lymphoma: BerEp4: Desmoplastic trichoepithelioma Basal cell carcinoma: Brown–Brenn: Eumycotic mycetoma: CAM 5.2: Merkel cell carcinoma: CCR7: Melanoma: Carcinoembryonic antigen (CEA) Eccrine gland ...
Prostate cancer: 1.5 million. Stomach cancer: 970,000. While lung cancer diagnoses slightly surpassed those of breast cancer in 2022, breast cancer remained the most common cause of cancer when ...
The term fibromatosis refers to a group of soft tissue tumors [1] which have certain characteristics in common, including absence of cytologic and clinical malignant features, a histology consistent with proliferation of well-differentiated fibroblasts, an infiltrative growth pattern, and aggressive clinical behavior with frequent local recurrence.
As of 2015, approximately 2.2 million individuals globally were living with cSCC at any given time, [8] constituting about 20% of all skin cancer cases. [21] In the United States, approximately 12% of males and 7% of females are diagnosed with cSCC at some point in their lives. [ 2 ]