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May cause respiratory depression when combined with benzodiazepines, barbiturates, codeine, or other muscle relaxants. [16] May cause urine to turn black, blue, or green. [14] While the product label states that methocarbamol can cause jaundice, there is minimal evidence to suggest that methocarbamol causes liver damage. [8]
Liver damage can be caused by viruses, alcohol, medications, and other hepatotoxins. [12] Acetaminophen, found in many prescription and over-the-counter medications, is the most common drug that can cause liver damage if taken in a high dose or in conjunction with alcohol. [12] Many liver transplant patients require the transplant because of ...
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval.
Data from the Drug Induced Liver Injury Network show that rates of liver injury from botanical products jumped from seven percent in 2004-2005 to 20 percent in 2013-2014.
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They have a direct toxic effect on the liver; cause inflammation of liver caused by and thereby impact lipid metabolism and fatty liver disease; and can translocate from the lungs to the liver. [46] Because particulate matter and carbon black are very diverse and each has different toxicodynamics, detailed mechanisms of translocation are not clear.
"The data does not allow a definitive answer, and there also appears to be significant variation among people in their susceptibility to liver damage from green tea," Dr. Clarke points out.
NAPQI, also known as NAPBQI or N-acetyl-p-benzoquinone imine, is a toxic byproduct produced during the xenobiotic metabolism of the analgesic paracetamol (acetaminophen). [1] It is normally produced only in small amounts, and then almost immediately detoxified in the liver.