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HAV IRES, entero-/rhinovirus and cardio-/apthovirus IRES are all approximately 450 nt but differ greatly in their structures. A cardiovirus, EMCV, and an apthovirus, foot-and-mouth disease virus (FMDV) share about 50% identical IRES elements. HCV-like picornavirus IRES incorporates the most difference in IRES elements from the other three classes.
IRES sequences were first discovered in 1988 in the poliovirus (PV) and encephalomyocarditis virus (EMCV) RNA genomes in the laboratories of Nahum Sonenberg [1] and Eckard Wimmer, [2] respectively. They are described as distinct regions of RNA molecules that are able to recruit the eukaryotic ribosome to the mRNA.
The N-myc internal ribosome entry site (IRES) is an RNA element found in the n-myc gene. The myc family of genes when expressed are known to be involved in the control of cell growth, differentiation and apoptosis. n-myc mRNA has an alternative method of translation via an internal ribosome entry site where ribosomes are recruited to the IRES located in the 5' UTR thus bypassing the typical ...
The RBS in prokaryotes is a region upstream of the start codon. This region of the mRNA has the consensus 5'-AGGAGG-3', also called the Shine-Dalgarno (SD) sequence. [1] The complementary sequence (CCUCCU), called the anti-Shine-Dalgarno (ASD) is contained in the 3’ end of the 16S region of the smaller (30S) ribosomal subunit.
A sequence profiling tool in bioinformatics is a type of software that presents information related to a genetic sequence, gene name, or keyword input. Such tools generally take a query such as a DNA , RNA , or protein sequence or ‘keyword’ and search one or more databases for information related to that sequence.
The Tobamovirus internal ribosome entry site (IRES) is an element that allows cap and end-independent translation of mRNA in the host cell. [1] The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor, eIF4F.
The c-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of C-myc and allows cap-independent translation. The mammalian c-myc gene is a proto-oncogene which is required for cell proliferation, transformation and death. c-myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the ...
The Cripavirus internal ribosome entry site (CrPV IRES) is an RNA element required for the production of capsid proteins through ribosome recruitment to an intergenic region IRES (IGR IRES). [1] A 3D representation of a Cripavirus IRES. This is a view of the tertiary structure of the ribosome-bound cricket paralysis virus IRES RNA. [1]
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