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Approximately 15–50% of people who suddenly stop an antidepressant develop antidepressant discontinuation syndrome. [7] [2] [3] [4] The condition is generally not serious, [2] though about half of people with symptoms describe them as severe. [4] Many restart antidepressants due to the severity of the symptoms. [4]
In some people, this state change can increase suicidal tendencies, especially in those under age 25 and during the initial weeks of treatment. [2] SSRI-induced activation syndrome is well-accepted by clinicians. [3] It is unclear whether jitteriness/anxiety syndrome predicts either good or poor prognosis (level D). [4]
Serotonin syndrome (SS) is a group of symptoms that may occur with the use of certain serotonergic medications or drugs. [1] The symptoms can range from mild to severe, and are potentially fatal.
Due to dextromethorphan's selective serotonin reuptake inhibitor-like action, the sudden cessation of recreational dosing in tolerant individuals can result in mental and physical withdrawal symptoms similar to the withdrawal from SSRIs. These withdrawal effects can manifest as psychological effects, including depression, irritability, cravings ...
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SSRIs can also induce apoptosis, programmed cell death, in T-cells. The full mechanism of action for the anti-inflammatory effects of SSRIs is not fully known. However, there is evidence for various pathways to have a hand in the mechanism. One such possible mechanism is the increased levels of cyclic adenosine monophosphate (cAMP) as a result ...
Researcher Vicky Williamson at Goldsmiths, University of London, found in an uncontrolled study that earworms correlated with music exposure, but could also be triggered by experiences that trigger the memory of a song (involuntary memory) such as seeing a word that reminds one of the song, hearing a few notes from the song, or feeling an emotion one associates with the song.
Antidepressant treatment tachyphylaxis (ADT tachyphylaxis), also known as Prozac poop-out, is a medical condition in which progressive or acute tolerance effects are seen following chronic administration of a drug. [1] It occurs more often with Selective serotonin reuptake inhibitors (SSRIs), which are the most commonly prescribed antidepressants.