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Structures with names 4- and 5-nitroimidazole are equivalent from the perspective of drugs since these tautomers readily interconvert. Drugs of the 5-nitro variety include metronidazole, tinidazole, nimorazole, dimetridazole, pretomanid, ornidazole, megazol, and azanidazole. Drugs based on 2-nitroimidazoles include benznidazole and azomycin. [3]
2-Methylimidazole is an organic compound that is structurally related to imidazole with the chemical formula CH 3 C 3 H 2 N 2 H. It is a white or colorless solid that is highly soluble in polar organic solvents and water. It is a precursor to a range of drugs and is a ligand in coordination chemistry.
2-Methylimidazole (1) may be prepared via the Debus-Radziszewski imidazole synthesis, or from ethylenediamine and acetic acid, followed by treatment with lime, then Raney nickel. 2-Methylimidazole is nitrated to give 2-methyl-4(5)-nitroimidazole (2), which is in turn alkylated with ethylene oxide or 2-chloroethanol to give metronidazole (3 ...
1-Methylimidazole or N-methylimidazole is an aromatic heterocyclic organic compound with the formula CH 3 C 3 H 3 N 2. It is a colourless liquid that is used as a specialty solvent, a base, and as a precursor to some ionic liquids.
Methylimidazole may refer to several related chemical compounds: 1-Methylimidazole; 2-Methylimidazole; 4-Methylimidazole, which is chemically distinct from, but ...
4-Methylimidazole (4-MeI or 4-MEI) is a heterocyclic organic chemical compound with molecular formula H 3 C – C 3 H 3 N 2 or C 4 H 6 N 2. It is formally derived from imidazole through replacement of the hydrogen in position 4 by a methyl group. It is a slightly yellowish solid.
BMIM-PF 6 is commercially available. It may be obtained in two steps: BMIM-Cl is synthesized by alkylating 1-methylimidazole with 1-chlorobutane.A metathesis reaction with potassium hexafluorophosphate gives the desired compound; the tetrafluoroborate may be prepared by analogously using potassium tetrafluoroborate.
The reaction of this with hydrazine gives 5-methyl-6-[3-nitro-4-(4-methoxy-benzoylamino)-phenyl]-3-oxo-4,5-dihydro-2H-pyridazine [74149-73-8]. Catalytic hydrogenation reduces the nitro group giving [74149-74-9] ( 4 ). cyclization of the resulting ortho amino amide by means of a strong acid leads to the formation of the corresponding benzimidazole.
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