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The more aggressive forms of disease require treatment with chemotherapy, radiotherapy, immunotherapy and—in some cases—a bone marrow transplant. The use of rituximab has been established for the treatment of B-cell–derived hematologic malignancies, including follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL).
Infiltration may refer to normal physiological processes, such as the infiltration of certain immune cells into peripheral tissues. Infiltration may also refer to pathological processes, such as malignant tumor cells infiltrating new areas of the human body, or small particles infiltrating tissues, where they may cause damage or inflammation.
The liver is then used as the main hematopoietic organ of the embryo until near birth, where it is then taken over by the bone marrow. [5] Most red blood cells are released into the blood as reticulocytes. Polychromasia occurs when the immature reticulocytes of the bone marrow are released, resulting in a grayish blue color of the cells.
of or relating to bone marrow or the spinal cord: Greek μυελός (muelós), marrow, bone-marrow myelin sheath, myeloblast: myl(o)-of or relating to molar teeth or the lower jaw Greek μῠ́λη (múlē, mill, grind, molars mylohyoid nerve: myri-ten thousand Greek μῡρῐ́ος (mūríos), innumerable, countless, infinite myriad: myring ...
Tumor immune infiltration can also be determined using gene expression methods like Microarray or RNA Sequencing through deconvolution methods such as CIBERSORT. [ 11 ] [ 12 ] Such methods allow for systematic TIL enumeration and characterization of the tumor microenvironment in diverse cancer types and across thousands of tumors, [ 12 ] [ 5 ...
Bone marrow samples can be obtained by aspiration and trephine biopsy. Sometimes, a bone marrow examination will include both an aspirate and a biopsy. The aspirate yields semi-liquid bone marrow, which can be examined by a pathologist under a light microscope and analyzed by flow cytometry, chromosome analysis, or polymerase chain reaction (PCR
Myelophthisic anemia (or myelophthisis) is a severe type of anemia found in some people with diseases that affect the bone marrow. Myelophthisis refers to the displacement of hemopoietic bone-marrow tissue [1] by fibrosis, tumors, or granulomas. The word comes from the roots myelo-, which refers to bone marrow, and phthisis, shrinkage or atrophy.
A subset of solitary plasmacytomas, termed solitary plasmacytoma with minimal bone marrow involvement, has the same criteria for diagnosis as solitary plasmacytoma except that bone marrow examination shows an increase in plasma cells from a normal value of ~0% to 1.5% to >~1.6% but less than 10% of total nucleated cells. While its presentations ...