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Relaxin is a protein hormone of about 6000 Da, [1] first described in 1926 by Frederick Hisaw. [2] [3]The relaxin family peptide hormones belong to the insulin superfamily and consists of seven peptides of high structural but low sequence similarity; relaxin-1 (RLN1), 2 (RLN2) and 3 (), and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6.
Relaxin family peptide hormones in humans are represented by seven members: three relaxin-like (RLN) and four insulin-like (INSL) peptides: RLN1, RLN2, RNL3, INSL3, INSL4, INSL5, INSL6. This subdivision into two classes (RLN and INSL) is based primarily on early findings, [ 1 ] and does not reflect the evolutionary origins or physiological ...
Relaxin is a hormone produced mainly by the corpus luteum of the ovary and breast, in both pregnant and non-pregnant females. During pregnancy it is also produced by the placenta, chorion, and decidua. The body produces relaxin during menstruation that rises to a peak within approximately 14 days of ovulation and then declines.
Women are 4-5 times more likely to develop a clot during pregnancy and in the postpartum period than when they are not pregnant. [25] Hypercoagulability in pregnancy likely evolved to protect women from hemorrhage at the time of miscarriage or childbirth. In developing countries, the leading cause of maternal death is still hemorrhage. [25]
As a paracrine hormone, relaxin helps the non-pregnant uterus become ready for pregnancy. [23] Women's endometrium contains relaxin, which is an essential component that helps prepare the body for early pregnancy. [21] The endometrium is transformed into decidua during the early pregnancy maintenance procedure. [21]
Relaxin-3 is a neuropeptide that was discovered in 2001, [1] and which is highly conserved in species ranging from flies, fish, rodents and humans. [2]
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51289 239336 Ensembl ENSG00000182631 ENSG00000277069 ENSMUSG00000060735 UniProt Q9NSD7 Q8BGE9 RefSeq (mRNA) NM_016568 NM_178717 RefSeq (protein) NP_057652 NP_848832 Location (UCSC) Chr 5: 33.94 – 33.94 Mb Chr 15: 11.03 – 11.04 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Relaxin/insulin-like family peptide receptor 3, also known as RXFP3, is a human G-protein coupled receptor ...