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Summation, which includes both spatial summation and temporal summation, is the process that determines whether or not an action potential will be generated by the combined effects of excitatory and inhibitory signals, both from multiple simultaneous inputs (spatial summation), and from repeated inputs (temporal summation).
The CMAP idealizes the summation of a group of almost simultaneous action potentials from several muscle fibers in the same area. These are usually evoked by stimulation of the motor nerve . Patients that suffer from critical illness myopathy , which is a frequent cause of weakness seen in patients in hospital intensive care units , have ...
The two ways that synaptic potentials can add up to potentially form an action potential are spatial summation and temporal summation. [5] Spatial summation refers to several excitatory stimuli from different synapses converging on the same postsynaptic neuron at the same time to reach the threshold needed to reach an action potential.
In neurophysiology, the Compound action potential (or CAP) refers to various evoked potentials representing the summation of synchronized individual action potentials generated by a group of neurons or muscle fibers in response to a stimulus. [1]
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A closely related summation method, also called Mittag-Leffler summation, is given as follows (Sansone & Gerretsen 1960). Suppose that the Borel transform B 1 y ( z ) {\displaystyle {\mathcal {B}}_{1}y(z)} converges to an analytic function near 0 that can be analytically continued along the positive real axis to a function growing sufficiently ...
Electrotonic potentials can sum spatially or temporally. Spatial summation is the combination of multiple sources of ion influx (multiple channels within a dendrite, or channels within multiple dendrites), whereas temporal summation is a gradual increase in overall charge due to repeated influxes in the same location. Because the ionic charge ...
[1] According to temporal summation one would expect the inhibitory and excitatory currents to be summed linearly to describe the resulting current entering the cell. However, when inhibitory and excitatory currents are on the soma of the cell, the inhibitory current causes the cell resistance to change (making the cell "leakier"), thereby ...